Assay Detail
Functional
CHEMBL708961
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the inhibition of mouse L1210 leukemia cell growth
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.44 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL171057 | — | — | 1 | 6.30 |
| CHEMBL352620 | — | — | 1 | 5.98 |
| CHEMBL56662 | — | — | 1 | 5.70 |
| CHEMBL301256 | — | — | 1 | 5.70 |
| CHEMBL171314 | — | — | 1 | 5.58 |
| CHEMBL169727 | — | — | 1 | 5.55 |
| CHEMBL169726 | — | — | 1 | 5.52 |
| CHEMBL353813 | — | — | 1 | 5.51 |
| CHEMBL168524 | — | — | 1 | 5.40 |
| CHEMBL353191 | — | — | 1 | 5.12 |
| CHEMBL169921 | — | — | 1 | 4.92 |
| CHEMBL353700 | — | — | 1 | 4.70 |
| CHEMBL169411 | — | — | 1 | 4.70 |
| CHEMBL172176 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL171057 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL352620 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL56662 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL301256 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL171314 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL169727 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL169726 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL353813 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL168524 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL353191 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL169921 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL353700 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL169411 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL172176 | — | IC50 | > | 10000.0 | nM | - |