Assay Detail
Functional
CHEMBL708985
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Concentration required to inhibit 50% of cell growth in L1210 murine leukemia cell line after 48 hr continuous treatment
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and cytotoxic activity of alkylidene- and alkyl-substituted camptothecins
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.47 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL353588 | — | — | 1 | 8.21 |
| CHEMBL352800 | — | — | 1 | 8.12 |
| CHEMBL355285 | — | — | 1 | 8.12 |
| CHEMBL274070 | 9-AMINOCAMPTOTHECIN | 2.0 | 1 | 7.90 |
| CHEMBL354671 | — | — | 1 | 7.80 |
| CHEMBL352709 | — | — | 1 | 7.79 |
| CHEMBL168505 | — | — | 1 | 7.21 |
| CHEMBL413917 | — | — | 1 | 6.92 |
| CHEMBL168822 | — | — | 1 | 6.74 |
| CHEMBL168975 | — | — | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL353588 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL352800 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL355285 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL274070 | 9-AMINOCAMPTOTHECIN | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL354671 | — | IC50 | = | 15.8 | nM | 7.80 |
| CHEMBL352709 | — | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL168505 | — | IC50 | = | 62.3 | nM | 7.21 |
| CHEMBL413917 | — | IC50 | = | 121.1 | nM | 6.92 |
| CHEMBL168822 | — | IC50 | = | 183.1 | nM | 6.74 |
| CHEMBL168975 | — | IC50 | = | 1184.9 | nM | 5.93 |