Assay Detail

CHEMBL708997

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Functional

Cytotoxicity expressed as concentration required to inhibit cell growth by 50% on continuous exposure time of 96h in L1210 cell line by MTT assay.

ChEMBL ↗

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Target

L1210 (CHEMBL386) ↗

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Primary target L1210

CHEMBL386

Anchored from Assay target.

Protein identity L1210

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Cell Type	L1210
Confidence	1 — Organism
Curated By	Intermediate

Target

L1210 (CHEMBL386) ↗

Type	CELL-LINE
Organism	Mus musculus

Publication

Synthesis and evaluation of water-soluble paclitaxel prodrugs.

Feng X, Yuan YJ, Wu JC.
Bioorg Med Chem Lett (2002) 12 : 3301 -3303
PubMed 12392737 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	10.05	10.05

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL428647	PACLITAXEL	4.0	1	10.05

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL428647	PACLITAXEL	IC50	=	0.09	nM	10.05