Assay Detail
Functional
CHEMBL709028
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Inhibitory concentration against LoVo cell proliferation, was determined using Cellular proliferation assays
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and evaluation of 4-anilino-6,7-dialkoxy-3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.32 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105220 | — | — | 1 | 8.30 |
| CHEMBL318804 | — | — | 1 | 8.30 |
| CHEMBL103045 | — | — | 1 | 8.15 |
| CHEMBL321045 | — | — | 1 | 8.15 |
| CHEMBL323515 | — | — | 1 | 8.00 |
| CHEMBL105642 | — | — | 1 | 7.44 |
| CHEMBL321078 | — | — | 1 | 7.44 |
| CHEMBL322857 | — | — | 1 | 7.37 |
| CHEMBL102786 | — | — | 1 | 7.25 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 6.88 |
| CHEMBL318326 | — | — | 1 | 6.70 |
| CHEMBL106489 | — | — | 1 | 6.49 |
| CHEMBL102374 | — | — | 1 | 6.47 |
| CHEMBL320688 | — | — | 1 | 6.42 |
| CHEMBL414139 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105220 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL318804 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL103045 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL321045 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL323515 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL105642 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL321078 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL322857 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL102786 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL105442 | CI-1040 | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL318326 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL106489 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL102374 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL320688 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL414139 | — | IC50 | = | 400.0 | nM | 6.40 |