Assay Detail
Functional
CHEMBL709032
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibit ion of MAPK phosphorylation in LoVo cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase; ERK1/ERK2 (CHEMBL1907606) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of 4-anilino-6,7-dialkoxy-3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.71 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318804 | — | — | 1 | 11.00 |
| CHEMBL414139 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318804 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL414139 | — | IC50 | = | 380.0 | nM | 6.42 |