Assay Detail
Functional
CHEMBL709037
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Inhibitory concentration was evaluated against colorectal tumar cell line LoVo
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
New mustard prodrugs for antibody-directed enzyme prodrug therapy: alternatives to the amide link.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.76 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12995 | — | — | 1 | 6.00 |
| CHEMBL275497 | — | — | 1 | 5.75 |
| CHEMBL518 | CHLORPHENACYL | — | 1 | 4.72 |
| CHEMBL12644 | — | — | 1 | 4.10 |
| CHEMBL276232 | — | — | 1 | 4.00 |
| CHEMBL274309 | — | — | 1 | 4.00 |
| CHEMBL12293 | — | — | 1 | - |
| CHEMBL276682 | — | — | 1 | - |
| CHEMBL12842 | — | — | 1 | - |
| CHEMBL274655 | — | — | 1 | - |
| CHEMBL12830 | — | — | 1 | - |
| CHEMBL13287 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12995 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL275497 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL518 | CHLORPHENACYL | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL12644 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL276232 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL274309 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL12293 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL276682 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL12842 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL274655 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL12830 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL13287 | — | IC50 | = | 200000.0 | nM | - |