Assay Detail
Functional
CHEMBL709038
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Inhibitory activity against human colon adenocarcinoma cell line LoVo.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Chromophore-modified antitumor anthracenediones: synthesis, DNA binding, and cytotoxic activity of 1,4-bis[(aminoalkyl)amino]benzo[g]-phthalazine-5,10-diones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.79 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 8.01 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.37 |
| CHEMBL150736 | — | — | 1 | 7.31 |
| CHEMBL542514 | — | — | 1 | 7.14 |
| CHEMBL544168 | — | — | 1 | 7.12 |
| CHEMBL356372 | — | — | 1 | 6.75 |
| CHEMBL150885 | — | — | 1 | 6.58 |
| CHEMBL49442 | AMETANTRONE | 2.0 | 1 | 6.24 |
| CHEMBL149467 | — | — | 1 | 5.85 |
| CHEMBL542513 | — | — | 1 | 5.57 |
| CHEMBL151165 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL150736 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL542514 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL544168 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL356372 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL150885 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL49442 | AMETANTRONE | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL149467 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL542513 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL151165 | — | IC50 | > | 8100.0 | nM | - |