Assay Detail

CHEMBL709039

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Functional

Tested against human colon carcinoma LoVo cell line in vitro

ChEMBL ↗

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Target

LoVo (CHEMBL614721) ↗

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Primary target LoVo

CHEMBL614721

Anchored from Assay target.

Protein identity LoVo

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	LoVo
Confidence	1 — Organism
Curated By	Intermediate

Target

LoVo (CHEMBL614721) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

2-substituted 1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3-diones. A new class of antitumor agent.

Sami SM, Dorr RT, Alberts DS, Remers WA.
J Med Chem (1993) 36 : 765 -770
PubMed 8459403 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.22	8.22

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL290677	AZONAFIDE	—	1	8.22

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL290677	AZONAFIDE	IC50	=	6.0	nM	8.22