Assay Detail
Functional
CHEMBL709040
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Tested in vitro for inhibition after 144 hr exposure against human colon carcinoma LoVo cell line
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and antitumor activity of a new class of pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone analogues of pyrrolo[1,4][2,1-c]benzodiazepines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.00 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL137702 | — | — | 1 | 8.05 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.24 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.39 |
| CHEMBL335927 | — | — | 1 | 4.82 |
| CHEMBL137476 | — | — | 1 | 4.57 |
| CHEMBL538159 | — | — | 1 | 4.52 |
| CHEMBL137657 | — | — | 1 | 4.43 |
| CHEMBL436566 | — | — | 1 | 4.40 |
| CHEMBL82340 | — | — | 1 | 4.38 |
| CHEMBL137603 | — | — | 1 | 4.34 |
| CHEMBL137629 | — | — | 1 | 4.32 |
| CHEMBL342020 | — | — | 1 | 4.27 |
| CHEMBL337104 | — | — | 1 | 4.27 |
| CHEMBL137503 | — | — | 1 | - |
| CHEMBL300842 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL137702 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL852 | MELPHALAN | IC50 | = | 4090.0 | nM | 5.39 |
| CHEMBL335927 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL137476 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL538159 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL137657 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL436566 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL82340 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL137603 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL137629 | — | IC50 | = | 48400.0 | nM | 4.32 |
| CHEMBL342020 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL337104 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL137503 | — | IC50 | > | 215000.0 | nM | - |
| CHEMBL300842 | — | IC50 | > | 162000.0 | nM | - |