Assay Detail
Functional
CHEMBL709043
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Inhibition of LoVo human colon tumor cell proliferation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
MEK (MAPKK) inhibitors. Part 2: structure-activity relationships of 4-anilino-3-cyano-6,7-dialkoxyquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.57 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414139 | — | — | 1 | 6.72 |
| CHEMBL30728 | — | — | 1 | 6.68 |
| CHEMBL29714 | — | — | 1 | 6.66 |
| CHEMBL31733 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414139 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL30728 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL29714 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL31733 | — | IC50 | = | 630.0 | nM | 6.20 |