Assay Detail
Functional
CHEMBL709062
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Inhibitory concentration against the growth of MCF-7 human breast carcinoma cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.68 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90904 | — | — | 1 | 7.47 |
| CHEMBL409088 | — | — | 1 | 7.38 |
| CHEMBL89341 | — | — | 1 | 7.35 |
| CHEMBL327414 | — | — | 1 | 6.43 |
| CHEMBL314534 | — | — | 1 | 6.40 |
| CHEMBL89039 | — | — | 1 | 6.34 |
| CHEMBL310038 | — | — | 1 | 6.28 |
| CHEMBL90441 | — | — | 1 | 6.25 |
| CHEMBL273425 | — | — | 1 | 6.19 |
| CHEMBL90926 | — | — | 1 | - |
| CHEMBL327181 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90904 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL409088 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL89341 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL327414 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL314534 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL89039 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL310038 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL90441 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL273425 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL90926 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL327181 | — | IC50 | > | 1000.0 | nM | - |