Assay Detail
Functional
CHEMBL709075
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against tubulin (1.0 mg/mL) assembly was determined
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antineoplastic agents. 487. Synthesis and biological evaluation of the antineoplastic agent 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene and derived amino acid amides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.58 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.68 |
| CHEMBL147075 | — | — | 1 | 5.54 |
| CHEMBL359307 | — | — | 1 | 5.51 |
| CHEMBL424131 | — | — | 1 | - |
| CHEMBL47037 | Combretastatin A-2 | — | 1 | - |
| CHEMBL150511 | — | — | 1 | - |
| CHEMBL147417 | — | — | 1 | - |
| CHEMBL347107 | — | — | 1 | - |
| CHEMBL150510 | — | — | 1 | - |
| CHEMBL150757 | — | — | 1 | - |
| CHEMBL148604 | — | — | 1 | - |
| CHEMBL151670 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL147075 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL359307 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL424131 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL47037 | Combretastatin A-2 | IC50 | = | 4.0 | ug.mL-1 | - |
| CHEMBL150511 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL147417 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL347107 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL150510 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL150757 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL148604 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL151670 | — | IC50 | > | 40000.0 | nM | - |