Assay Detail
Functional
CHEMBL709123
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-proliferative activity against MCF-7 human breast cancer cells was determined by using MCF-7 plate assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
2-Alkylsulfanyl estrogen derivatives: synthesis of a novel class of multi-targeted anti-tumour agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.23 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL362734 | — | — | 1 | 6.40 |
| CHEMBL366186 | — | — | 1 | 6.37 |
| CHEMBL299613 | 2-METHOXYESTRADIOL | 2.0 | 1 | 5.62 |
| CHEMBL190575 | — | — | 1 | 5.40 |
| CHEMBL122708 | EMATE | — | 1 | 4.64 |
| CHEMBL365571 | — | — | 1 | 4.50 |
| CHEMBL363000 | — | — | 1 | 4.48 |
| CHEMBL434727 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL362734 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL366186 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL299613 | 2-METHOXYESTRADIOL | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL190575 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL122708 | EMATE | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL365571 | — | IC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL363000 | — | IC50 | = | 33400.0 | nM | 4.48 |
| CHEMBL434727 | — | IC50 | = | 35300.0 | nM | 4.45 |