Assay Detail
Functional
CHEMBL709129
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Cytotoxic effect on MCF-7 human breast carcinoma cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structural studies on bioactive compounds. 23. Synthesis of polyhydroxylated 2-phenylbenzothiazoles and a comparison of their cytotoxicities and pharmacological properties with genistein and quercetin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.80 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44326 | — | — | 1 | 5.57 |
| CHEMBL411 | DIETHYLSTILBESTROL | 4.0 | 1 | 5.30 |
| CHEMBL46786 | — | — | 1 | 5.29 |
| CHEMBL48033 | — | — | 1 | 5.08 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 4.82 |
| CHEMBL295539 | — | — | 1 | 4.75 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.62 |
| CHEMBL44227 | — | — | 1 | 4.60 |
| CHEMBL47875 | — | — | 1 | 4.57 |
| CHEMBL47361 | — | — | 1 | 4.56 |
| CHEMBL45564 | — | — | 1 | 4.48 |
| CHEMBL48085 | — | — | 1 | 4.38 |
| CHEMBL43722 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44326 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL411 | DIETHYLSTILBESTROL | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL46786 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL48033 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL44 | GENISTEIN | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL295539 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL50 | QUERCETIN | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL44227 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL47875 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL47361 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL45564 | — | IC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL48085 | — | IC50 | = | 41300.0 | nM | 4.38 |
| CHEMBL43722 | — | IC50 | = | 41400.0 | nM | 4.38 |