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Assay Detail

CHEMBL709169

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of specific binding of [3H]-LTB4 to LTB4 receptor in guinea pig lung membranes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Tissue Lung
Subcellular Membrane
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Leukotriene B4 receptor (CHEMBL2095160)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Diaryl ether/carboxylic acid derivatives of LY255283: Receptor antagonists of leukotriene B4
Scott Sawyer J, Baldwin RF, Saussy DL, Froelich LL, Jackson WT
Bioorg Med Chem Lett (1993) 3 : 1985 -1990
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 7.22 9.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL65061 LEUKOTRIENE_B4 1 9.92
CHEMBL14823 SC-41390 1 7.82
CHEMBL61542 1 7.41
CHEMBL61919 1 7.23
CHEMBL15766 LY-255283 1 7.11
CHEMBL303109 1 7.05
CHEMBL61920 1 6.89
CHEMBL59656 1 6.85
CHEMBL61913 1 6.61
CHEMBL61770 1 6.59
CHEMBL61063 1 5.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL65061 LEUKOTRIENE_B4 Ki = 0.12 nM 9.92
CHEMBL14823 SC-41390 Ki = 15.0 nM 7.82
CHEMBL61542 Ki = 39.0 nM 7.41
CHEMBL61919 Ki = 59.0 nM 7.23
CHEMBL15766 LY-255283 Ki = 77.0 nM 7.11
CHEMBL303109 Ki = 90.0 nM 7.05
CHEMBL61920 Ki = 130.0 nM 6.89
CHEMBL59656 Ki = 140.0 nM 6.85
CHEMBL61913 Ki = 244.0 nM 6.61
CHEMBL61770 Ki = 256.0 nM 6.59
CHEMBL61063 Ki = 1200.0 nM 5.92