Assay Detail
Binding
CHEMBL709173
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Inhibition of human MMP-3.
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.09 | 8.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417537 | — | — | 1 | 8.71 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 8.62 |
| CHEMBL88718 | — | — | 1 | 8.54 |
| CHEMBL92385 | — | — | 1 | 8.52 |
| CHEMBL23725 | — | — | 1 | 8.52 |
| CHEMBL24761 | — | — | 1 | 8.47 |
| CHEMBL91636 | — | — | 1 | 8.11 |
| CHEMBL88520 | — | — | 1 | 7.85 |
| CHEMBL328090 | — | — | 1 | 7.79 |
| CHEMBL329124 | — | — | 1 | 7.65 |
| CHEMBL48258 | — | — | 1 | 7.62 |
| CHEMBL45631 | — | — | 1 | 7.49 |
| CHEMBL433381 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417537 | — | Ki | = | 1.93 | nM | 8.71 |
| CHEMBL279785 | MARIMASTAT | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL88718 | — | Ki | = | 2.88 | nM | 8.54 |
| CHEMBL92385 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL23725 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL24761 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL91636 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL88520 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL328090 | — | Ki | = | 16.2 | nM | 7.79 |
| CHEMBL329124 | — | Ki | = | 22.3 | nM | 7.65 |
| CHEMBL48258 | — | Ki | = | 24.1 | nM | 7.62 |
| CHEMBL45631 | — | Ki | = | 32.7 | nM | 7.49 |
| CHEMBL433381 | — | Ki | = | 48.0 | nM | 7.32 |