Assay Detail
Binding
CHEMBL709175
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human matrix metalloprotease-3
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of selective azasugar-based TACE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.80 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43087 | — | — | 1 | 8.48 |
| CHEMBL41821 | — | — | 1 | 7.94 |
| CHEMBL288664 | — | — | 1 | 7.53 |
| CHEMBL288843 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43087 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL41821 | — | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL288664 | — | Ki | = | 29.6 | nM | 7.53 |
| CHEMBL288843 | — | Ki | = | 58.05 | nM | 7.24 |