Assay Detail
Binding
CHEMBL709179
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Inhibition of Matrix metalloprotease-3
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Macrocyclic amino carboxylates as selective MMP-8 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.07 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48256 | — | — | 1 | 5.62 |
| CHEMBL298167 | — | — | 1 | 5.54 |
| CHEMBL50228 | — | — | 1 | 4.87 |
| CHEMBL48786 | — | — | 1 | 4.85 |
| CHEMBL46183 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48256 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL298167 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL50228 | — | Ki | = | 13500.0 | nM | 4.87 |
| CHEMBL48786 | — | Ki | = | 14088.0 | nM | 4.85 |
| CHEMBL46183 | — | Ki | = | 35000.0 | nM | 4.46 |