Assay Detail
Binding
CHEMBL709186
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Inhibition of Matrix Metalloprotease-3
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Rational design and combinatorial evaluation of enzyme inhibitor scaffolds: identification of novel inhibitors of matrix metalloproteinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.32 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69323 | — | — | 1 | 5.62 |
| CHEMBL305024 | — | — | 1 | 5.47 |
| CHEMBL29897 | — | — | 1 | 5.42 |
| CHEMBL30034 | — | — | 1 | 5.39 |
| CHEMBL69194 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69323 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL305024 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL29897 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL30034 | — | IC50 | = | 4045.0 | nM | 5.39 |
| CHEMBL69194 | — | IC50 | = | 19000.0 | nM | 4.72 |