Assay Detail
Functional
CHEMBL709286
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Tested for inhibitory activity against murine cell line L12110, a strain sensitive to doxorubicin using MTT assay.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Analogues of amonafide and azonafide with novel ring systems.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.88 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290677 | AZONAFIDE | — | 1 | 8.15 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 8.00 |
| CHEMBL105650 | — | — | 1 | 7.96 |
| CHEMBL321274 | — | — | 1 | 7.96 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.46 |
| CHEMBL319702 | — | — | 1 | 7.37 |
| CHEMBL318355 | — | — | 1 | 7.30 |
| CHEMBL107783 | — | — | 1 | 7.27 |
| CHEMBL104820 | — | — | 1 | 7.27 |
| CHEMBL106541 | — | — | 1 | 7.22 |
| CHEMBL321071 | — | — | 1 | 7.14 |
| CHEMBL105266 | — | — | 1 | 6.71 |
| CHEMBL105615 | — | — | 1 | 6.63 |
| CHEMBL105797 | — | — | 1 | 6.59 |
| CHEMBL324189 | — | — | 1 | 6.37 |
| CHEMBL105035 | — | — | 1 | 6.28 |
| CHEMBL105443 | — | — | 1 | 6.27 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 6.20 |
| CHEMBL323455 | — | — | 1 | 6.12 |
| CHEMBL318380 | — | — | 1 | 6.11 |
| CHEMBL105503 | — | — | 1 | 6.09 |
| CHEMBL105277 | — | — | 1 | 6.01 |
| CHEMBL319187 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290677 | AZONAFIDE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL105650 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL321274 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL319702 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL318355 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL107783 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL104820 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL106541 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL321071 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL105266 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL105615 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL105797 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL324189 | — | IC50 | = | 424.0 | nM | 6.37 |
| CHEMBL105035 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL105443 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL323455 | — | IC50 | = | 751.0 | nM | 6.12 |
| CHEMBL318380 | — | IC50 | = | 769.0 | nM | 6.11 |
| CHEMBL105503 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL105277 | — | IC50 | = | 984.0 | nM | 6.01 |
| CHEMBL319187 | — | IC50 | = | 2186.0 | nM | 5.66 |