Assay Detail
Binding
CHEMBL709291
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Inhibition of L244A mutant cytochrome P450cam expressed in Escherichia coli
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Computer-assisted design of selective imidazole inhibitors for cytochrome p450 enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.76 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL120774 | — | — | 1 | 5.19 |
| CHEMBL333092 | — | — | 1 | 5.00 |
| CHEMBL120100 | — | — | 1 | 4.44 |
| CHEMBL334002 | — | — | 1 | 4.39 |
| CHEMBL118854 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL120774 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL333092 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL120100 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL334002 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL118854 | — | IC50 | = | 129000.0 | nM | - |