Assay Detail
Functional
CHEMBL709418
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Inhibitory activity against MDA-468 cell line using MTT assay (ER-, amplified EGFR, mutant p53)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.73 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.30 |
| CHEMBL41701 | — | — | 1 | 7.40 |
| CHEMBL41700 | — | — | 1 | 7.40 |
| CHEMBL41526 | — | — | 1 | 7.05 |
| CHEMBL38451 | — | — | 1 | 6.77 |
| CHEMBL43453 | — | — | 1 | 6.75 |
| CHEMBL41863 | — | — | 1 | 6.51 |
| CHEMBL43229 | — | — | 1 | 6.50 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 6.31 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.22 |
| CHEMBL41174 | — | — | 1 | 5.86 |
| CHEMBL291263 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL41701 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL41700 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL41526 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL38451 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL43453 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL41863 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL43229 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL43 | AMSACRINE | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL41174 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL291263 | — | IC50 | = | 1870.0 | nM | 5.73 |