Assay Detail
Binding
CHEMBL709520
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In vitro inhibition of recombinant human matrix metalloprotease-3 (MMP-3)
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available biphenylsulfonamide matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.84 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43113 | — | — | 1 | 8.52 |
| CHEMBL432882 | — | — | 1 | 8.40 |
| CHEMBL433262 | — | — | 1 | 8.30 |
| CHEMBL42938 | — | — | 1 | 8.30 |
| CHEMBL43479 | — | — | 1 | 8.30 |
| CHEMBL45040 | — | — | 1 | 8.22 |
| CHEMBL43152 | — | — | 1 | 8.15 |
| CHEMBL44062 | — | — | 1 | 8.15 |
| CHEMBL47076 | — | — | 1 | 8.15 |
| CHEMBL42420 | — | — | 1 | 8.10 |
| CHEMBL44383 | — | — | 1 | 8.10 |
| CHEMBL46830 | — | — | 1 | 8.10 |
| CHEMBL296196 | — | — | 1 | 8.05 |
| CHEMBL47254 | — | — | 1 | 8.05 |
| CHEMBL44898 | — | — | 1 | 8.00 |
| CHEMBL418442 | — | — | 1 | 8.00 |
| CHEMBL43063 | — | — | 1 | 8.00 |
| CHEMBL432307 | — | — | 1 | 7.92 |
| CHEMBL44455 | — | — | 1 | 7.82 |
| CHEMBL46818 | — | — | 1 | 7.80 |
| CHEMBL539683 | — | — | 1 | 7.77 |
| CHEMBL43276 | — | — | 1 | 7.70 |
| CHEMBL297749 | — | — | 1 | 7.68 |
| CHEMBL295871 | — | — | 1 | 7.66 |
| CHEMBL291133 | — | — | 1 | 7.55 |
| CHEMBL42114 | — | — | 1 | 7.44 |
| CHEMBL43147 | — | — | 1 | 7.42 |
| CHEMBL42067 | — | — | 1 | 6.87 |
| CHEMBL43206 | — | — | 1 | 6.54 |
| CHEMBL43644 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43113 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL432882 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL433262 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL42938 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL43479 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL45040 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL43152 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL44062 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL47076 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL42420 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL44383 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL46830 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL296196 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL47254 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL44898 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL418442 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL43063 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL432307 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL44455 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL46818 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL539683 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL43276 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL297749 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL295871 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL291133 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL42114 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL43147 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL42067 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL43206 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL43644 | — | IC50 | = | 810.0 | nM | 6.09 |