Assay Detail
Binding
CHEMBL709764
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In vitro ability to displace [3H]glutamate binding to metabotropic glutamate receptors in rat forebrain membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Forebrain |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.09 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40086 | — | — | 1 | 5.19 |
| CHEMBL34453 | — | — | 1 | 4.99 |
| CHEMBL323097 | — | — | 1 | - |
| CHEMBL103452 | — | — | 1 | - |
| CHEMBL431998 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40086 | — | IC50 | = | 6490.0 | nM | 5.19 |
| CHEMBL34453 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL323097 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL103452 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL431998 | — | IC50 | > | 100000.0 | nM | - |