Assay Detail
Functional
CHEMBL709771
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Agonist activity against Metabotropic glutamate receptor 1 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.03 | 5.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34453 | — | — | 1 | 5.03 |
| CHEMBL36988 | — | — | 1 | - |
| CHEMBL107845 | — | — | 1 | - |
| CHEMBL29726 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34453 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL36988 | — | EC50 | = | 127000.0 | nM | - |
| CHEMBL107845 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL29726 | — | EC50 | > | 300000.0 | nM | - |