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Assay Detail

CHEMBL709820

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of growth of MCF-7 human breast adenocarcinoma using 72 hours continuous exposure
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Tissue Breast
Cell Type MCF7
Confidence 1 — Organism
Curated By Intermediate

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents.
Bigham EC, Hodson SJ, Mallory WR, Wilson D, Duch DS, Smith GK, Ferone R.
J Med Chem (1992) 35 : 1399 -1410
PubMed 1573633 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.30 5.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL30364 1 5.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL30364 IC50 = 5000.0 nM 5.30