Assay Detail
Functional
CHEMBL709828
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In vitro inhibition of MCF-7 cell proliferation compared to 0.1 nM [3H]-estradiol.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Effect of triphenylacrylonitrile derivatives on estradiol-receptor binding and on human breast cancer cell growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.64 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2137046 | — | — | 1 | 8.60 |
| CHEMBL65053 | — | — | 1 | 8.46 |
| CHEMBL63877 | — | — | 1 | 8.34 |
| CHEMBL293234 | — | — | 1 | 8.32 |
| CHEMBL63835 | — | — | 1 | 8.02 |
| CHEMBL302647 | — | — | 1 | 7.77 |
| CHEMBL279301 | — | — | 1 | 7.66 |
| CHEMBL66352 | — | — | 1 | 7.60 |
| CHEMBL308006 | — | — | 1 | 7.57 |
| CHEMBL293174 | — | — | 1 | 7.50 |
| CHEMBL65427 | — | — | 1 | 7.47 |
| CHEMBL65499 | — | — | 1 | 7.47 |
| CHEMBL291639 | — | — | 1 | 7.28 |
| CHEMBL64910 | — | — | 1 | 6.83 |
| CHEMBL417964 | — | — | 1 | 6.75 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 6.66 |
| CHEMBL67727 | — | — | 1 | - |
| CHEMBL68236 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2137046 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL65053 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL63877 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL293234 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL63835 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL302647 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL279301 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL66352 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL308006 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL293174 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL65427 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL65499 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL291639 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL64910 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL417964 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL67727 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL68236 | — | IC50 | > | 1000.0 | nM | - |