Assay Detail
Functional
CHEMBL709979
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Cytotoxicity of compound was tested against MCF-7 breast cancer cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of a series of fluoroquinoanthroxazines with contrasting dual mechanisms of action against topoisomerase II and G-quadruplexes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.63 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346068 | — | — | 1 | 6.34 |
| CHEMBL155344 | — | — | 1 | 5.96 |
| CHEMBL350251 | — | — | 1 | 5.37 |
| CHEMBL154276 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346068 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL155344 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL350251 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL154276 | — | IC50 | = | 14200.0 | nM | 4.85 |