Assay Detail
Functional
CHEMBL709980
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against adriamycin resistant human breast MCF-7 cancer cell lines
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of 3-alkyl- and 3-alkenyl-3-dephenyldocetaxels
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.32 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339531 | — | — | 1 | 7.92 |
| CHEMBL89290 | — | — | 1 | 7.92 |
| CHEMBL313351 | — | — | 1 | 7.85 |
| CHEMBL315858 | — | — | 1 | 7.44 |
| CHEMBL89997 | — | — | 1 | 6.95 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 6.63 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339531 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL89290 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL313351 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL315858 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL89997 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 300.0 | nM | 6.52 |