Assay Detail
Functional
CHEMBL710041
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Induction of pS2 Gene expression in human MCF-7 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 4-(hydroxyalkyl)estradiols and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.60 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 10.52 |
| CHEMBL1627574 | — | — | 1 | 7.93 |
| CHEMBL1412489 | — | — | 1 | 7.18 |
| CHEMBL1627561 | — | — | 1 | 6.83 |
| CHEMBL1627932 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | EC50 | = | 0.0301 | nM | 10.52 |
| CHEMBL1627574 | — | EC50 | = | 11.7 | nM | 7.93 |
| CHEMBL1412489 | — | EC50 | = | 65.4 | nM | 7.18 |
| CHEMBL1627561 | — | EC50 | = | 148.0 | nM | 6.83 |
| CHEMBL1627932 | — | EC50 | = | 2950.0 | nM | 5.53 |