Assay Detail
Functional
CHEMBL710042
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Induction of pS2 mRNA expression in human MCF-7 mammary carcinoma cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
2-(Hydroxyalkyl)estradiols: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.43 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 10.00 |
| CHEMBL1627431 | — | — | 1 | 7.99 |
| CHEMBL1628150 | — | — | 1 | 6.57 |
| CHEMBL467987 | — | — | 1 | 6.30 |
| CHEMBL1627420 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | EC50 | = | 0.0996 | nM | 10.00 |
| CHEMBL1627431 | — | EC50 | = | 10.3 | nM | 7.99 |
| CHEMBL1628150 | — | EC50 | = | 272.0 | nM | 6.57 |
| CHEMBL467987 | — | EC50 | = | 504.0 | nM | 6.30 |
| CHEMBL1627420 | — | EC50 | = | 495.0 | nM | 6.30 |