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Assay Detail

CHEMBL710053

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity was measured against neoplastic cultured MEL-28 cells of malign human melanoma.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-MEL-28
Confidence 1 — Organism
Curated By Expert

Target

SK-MEL-28 (CHEMBL614919)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and bioactivity of new antineoplastic terpenylquinones
Gordaliza M, Miguel del Corral J, Angeles Castro M, Mar Mahiques M, Garcia-Gravalos M, San Feliciano A
Bioorg Med Chem Lett (1996) 6 : 1859 -1864
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.22 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL55858 1 6.40
CHEMBL55266 1 5.68
CHEMBL55668 1 5.46
CHEMBL55943 1 5.44
CHEMBL58884 1 5.31
CHEMBL459814 AVAROL 1 5.22
CHEMBL464645 AVARONE 1 5.22
CHEMBL55265 1 5.01
CHEMBL55854 1 5.01
CHEMBL53458 1 4.84
CHEMBL55952 1 4.71
CHEMBL8320 BENZOQUINONE 1 4.33
CHEMBL52618 1 -
CHEMBL300122 1 -
CHEMBL55934 NAPHTHOQUINONE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL55858 IC50 = 400.0 nM 6.40
CHEMBL55266 IC50 = 2100.0 nM 5.68
CHEMBL55668 IC50 = 3500.0 nM 5.46
CHEMBL55943 IC50 = 3600.0 nM 5.44
CHEMBL58884 IC50 = 4900.0 nM 5.31
CHEMBL459814 AVAROL IC50 = 6000.0 nM 5.22
CHEMBL464645 AVARONE IC50 = 6000.0 nM 5.22
CHEMBL55265 IC50 = 9800.0 nM 5.01
CHEMBL55854 IC50 = 9800.0 nM 5.01
CHEMBL53458 IC50 = 14600.0 nM 4.84
CHEMBL55952 IC50 = 19400.0 nM 4.71
CHEMBL8320 BENZOQUINONE IC50 = 46200.0 nM 4.33
CHEMBL52618 IC50 > 34000.0 nM -
CHEMBL300122 IC50 > 34000.0 nM -
CHEMBL55934 NAPHTHOQUINONE IC50 > 63200.0 nM -