Assay Detail
Functional
CHEMBL710055
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity against MEL-28 (human malign melanoma) neoplastic cell line
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-28 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and cytotoxicity of hydrophobic esters of podophyllotoxins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.82 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2096915 | — | — | 2 | 8.40 |
| CHEMBL441544 | — | — | 1 | 7.72 |
| CHEMBL23448 | — | — | 1 | 7.68 |
| CHEMBL278995 | — | — | 1 | 7.32 |
| CHEMBL23606 | — | — | 1 | 7.28 |
| CHEMBL283767 | — | — | 1 | 7.03 |
| CHEMBL23474 | — | — | 1 | 6.74 |
| CHEMBL23372 | — | — | 1 | 6.73 |
| CHEMBL424217 | — | — | 1 | 6.72 |
| CHEMBL281873 | — | — | 1 | 6.67 |
| CHEMBL277216 | — | — | 1 | 6.67 |
| CHEMBL282267 | — | — | 1 | 6.34 |
| CHEMBL386429 | — | — | 1 | 6.33 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.07 |
| CHEMBL402665 | — | — | 1 | 5.95 |
| CHEMBL277901 | — | — | 1 | 5.71 |
| CHEMBL23806 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2096915 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2096915 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL441544 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL23448 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL278995 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL23606 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL283767 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL23474 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL23372 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL424217 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL281873 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL277216 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL282267 | — | IC50 | = | 454.0 | nM | 6.34 |
| CHEMBL386429 | — | IC50 | = | 468.0 | nM | 6.33 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL402665 | — | IC50 | = | 1122.0 | nM | 5.95 |
| CHEMBL277901 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL23806 | — | IC50 | = | 9182.0 | nM | 5.04 |