Assay Detail
Functional
CHEMBL710061
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Cytotoxicity against MEL-AC melanoma cell line
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MEL-AC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and cytotoxic activity of N-(2-pyridylsulfenyl)urea derivatives. A new class of potential antineoplastic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.48 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77950 | — | — | 1 | 6.70 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.92 |
| CHEMBL75064 | — | — | 1 | 5.92 |
| CHEMBL309813 | — | — | 1 | 4.47 |
| CHEMBL77093 | — | — | 1 | 4.37 |
| CHEMBL430989 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77950 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL75064 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL309813 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL77093 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL430989 | — | IC50 | > | 100000.0 | nM | - |