Assay Detail

CHEMBL710072

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Functional

Intracellular uptake of drug in presence of 3H VBL and VRP in HET-SR-2SC-LNM cell line

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Cricetulus griseus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Effects of isoprenoid analogues of SDB-ethylenediamine on multidrug resistant tumor cells alone and in combination with chemotherapeutic drugs.

Sidorova TA, Nigmatov AG, Kakpakova ES, Stavrovskaya AA, Gerassimova GK, Shtil AA, Serebryakov EP.
J Med Chem (2002) 45 : 5330 -5339
PubMed 12431060 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.54	7.54

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1280	VERAPAMIL HYDROCHLORIDE	4.0	1	7.54

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1280	VERAPAMIL HYDROCHLORIDE	IC50	=	29.0	nM	7.54