Assay Detail
Functional
CHEMBL710083
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Tested for in vitro cytostatic activity against human lymphoblast Molt-4 (Clone8)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nucleic acid related compounds. 84. Synthesis of 6'-(E and Z)-halohomovinyl derivatives of adenosine, inactivation of S-adenosyl-L-homocysteine hydrolase, and correlation of anticancer and antiviral potencies with enzyme inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.51 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL604208 | — | — | 1 | 5.00 |
| CHEMBL608056 | — | — | 1 | 4.75 |
| CHEMBL206231 | — | — | 1 | 4.68 |
| CHEMBL608344 | — | — | 1 | 4.50 |
| CHEMBL2092790 | — | — | 1 | 4.10 |
| CHEMBL2092958 | — | — | 1 | 4.03 |
| CHEMBL2092957 | — | — | 1 | - |
| CHEMBL610125 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL604208 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL608056 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL206231 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL608344 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL2092790 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL2092958 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL2092957 | — | IC50 | = | 117000.0 | nM | - |
| CHEMBL610125 | — | IC50 | = | 266000.0 | nM | - |