Assay Detail
Functional
CHEMBL710091
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Ability to inhibit the growth of MDA-MB-231 cell line
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.36 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86881 | — | — | 1 | 5.85 |
| CHEMBL89475 | — | — | 1 | 5.70 |
| CHEMBL89859 | — | — | 1 | 5.70 |
| CHEMBL89858 | — | — | 1 | 5.70 |
| CHEMBL89366 | — | — | 1 | 5.68 |
| CHEMBL91727 | — | — | 1 | 5.66 |
| CHEMBL88230 | — | — | 1 | 5.62 |
| CHEMBL423684 | — | — | 1 | 5.60 |
| CHEMBL88947 | — | — | 1 | 5.57 |
| CHEMBL88268 | — | — | 1 | 5.57 |
| CHEMBL329397 | — | — | 1 | 5.55 |
| CHEMBL421545 | — | — | 1 | 5.54 |
| CHEMBL90563 | — | — | 1 | 5.54 |
| CHEMBL433412 | — | — | 1 | 5.47 |
| CHEMBL89080 | — | — | 1 | 5.44 |
| CHEMBL91078 | — | — | 1 | 5.37 |
| CHEMBL91650 | — | — | 1 | 5.35 |
| CHEMBL89211 | — | — | 1 | 5.34 |
| CHEMBL91726 | — | — | 1 | 5.33 |
| CHEMBL88831 | — | — | 1 | 5.31 |
| CHEMBL313317 | — | — | 1 | 5.30 |
| CHEMBL328520 | — | — | 1 | 5.28 |
| CHEMBL312843 | — | — | 1 | 5.28 |
| CHEMBL89232 | — | — | 1 | 5.19 |
| CHEMBL440697 | — | — | 1 | 5.14 |
| CHEMBL89726 | — | — | 1 | 5.12 |
| CHEMBL91371 | — | — | 1 | 5.11 |
| CHEMBL316338 | — | — | 1 | 5.10 |
| CHEMBL419314 | — | — | 1 | 5.09 |
| CHEMBL439585 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86881 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL89475 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL89858 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL89859 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL89366 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL91727 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL88230 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL423684 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL88947 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL88268 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL329397 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL421545 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL90563 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL433412 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL89080 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL91078 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL91650 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL89211 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL91726 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL88831 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL313317 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL328520 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL312843 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL89232 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL440697 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL89726 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL91371 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL316338 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL419314 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL439585 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL88438 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL86449 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL90439 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL90494 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL329895 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL89586 | — | IC50 | > | 10000.0 | nM | - |