Assay Detail
Binding
CHEMBL710107
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Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method maltase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.30 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75971 | — | — | 1 | 6.92 |
| CHEMBL1029 | MIGLUSTAT | 4.0 | 1 | 5.68 |
| CHEMBL77918 | — | — | 1 | - |
| CHEMBL310229 | — | — | 1 | - |
| CHEMBL310231 | — | — | 1 | - |
| CHEMBL312653 | — | — | 1 | - |
| CHEMBL80148 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75971 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1029 | MIGLUSTAT | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL77918 | — | IC50 | < | 50000.0 | nM | - |
| CHEMBL310229 | — | IC50 | < | 50000.0 | nM | - |
| CHEMBL310231 | — | IC50 | < | 50000.0 | nM | - |
| CHEMBL312653 | — | IC50 | < | 50000.0 | nM | - |
| CHEMBL80148 | — | IC50 | = | 500000.0 | nM | - |