Assay Detail
Binding
CHEMBL710127
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Inhibitory activity against human matrix metalloprotease-3 (MMP-3) (at pH 7.4)
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.30 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10953 | — | — | 1 | 6.11 |
| CHEMBL10672 | — | — | 1 | 5.88 |
| CHEMBL10952 | — | — | 1 | 5.74 |
| CHEMBL10454 | — | — | 1 | 5.64 |
| CHEMBL10266 | — | — | 1 | 5.63 |
| CHEMBL275130 | — | — | 1 | 5.62 |
| CHEMBL10908 | — | — | 1 | 5.54 |
| CHEMBL10809 | — | — | 1 | 5.48 |
| CHEMBL10671 | — | — | 1 | 5.47 |
| CHEMBL10673 | — | — | 1 | 5.45 |
| CHEMBL10655 | — | — | 1 | 5.45 |
| CHEMBL10935 | — | — | 1 | 5.43 |
| CHEMBL275700 | — | — | 1 | 5.41 |
| CHEMBL274881 | — | — | 1 | 5.39 |
| CHEMBL276016 | — | — | 1 | 5.37 |
| CHEMBL10257 | — | — | 1 | 5.36 |
| CHEMBL10822 | — | — | 1 | 5.34 |
| CHEMBL10760 | — | — | 1 | 5.34 |
| CHEMBL10335 | — | — | 1 | 5.30 |
| CHEMBL10674 | — | — | 1 | 5.29 |
| CHEMBL10881 | — | — | 1 | 5.26 |
| CHEMBL10431 | — | — | 1 | 5.18 |
| CHEMBL10761 | — | — | 1 | 5.06 |
| CHEMBL10848 | — | — | 1 | 5.05 |
| CHEMBL10469 | — | — | 1 | 5.05 |
| CHEMBL10590 | — | — | 1 | 5.00 |
| CHEMBL10806 | — | — | 1 | 4.97 |
| CHEMBL10792 | — | — | 1 | 4.84 |
| CHEMBL407640 | — | — | 1 | 4.81 |
| CHEMBL274174 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10953 | — | IC50 | = | 777.0 | nM | 6.11 |
| CHEMBL10672 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL10952 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL10454 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL10266 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL275130 | — | IC50 | = | 2428.0 | nM | 5.62 |
| CHEMBL10908 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL10809 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL10671 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL10673 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL10655 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL10935 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL275700 | — | IC50 | = | 3920.0 | nM | 5.41 |
| CHEMBL274881 | — | IC50 | = | 4090.0 | nM | 5.39 |
| CHEMBL276016 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL10257 | — | IC50 | = | 4360.0 | nM | 5.36 |
| CHEMBL10822 | — | IC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL10760 | — | IC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL10335 | — | IC50 | = | 5060.0 | nM | 5.30 |
| CHEMBL10674 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL10881 | — | IC50 | = | 5440.0 | nM | 5.26 |
| CHEMBL10431 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL10761 | — | IC50 | = | 8620.0 | nM | 5.06 |
| CHEMBL10848 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL10469 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL10590 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL10806 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL10792 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL407640 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL274174 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL10296 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL10180 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL275754 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10193 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10646 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL11188 | — | IC50 | > | 9999.0 | nM | - |
| CHEMBL11005 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10492 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL274997 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL268050 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10851 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL275345 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10885 | — | IC50 | > | 10000.0 | nM | - |