Assay Detail
Binding
CHEMBL710130
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Inhibition of Matrix metalloprotease-3
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.81 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317508 | — | — | 1 | 8.96 |
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 8.96 |
| CHEMBL317132 | — | — | 1 | 8.49 |
| CHEMBL100584 | — | — | 1 | 8.37 |
| CHEMBL323371 | — | — | 1 | 8.30 |
| CHEMBL101121 | — | — | 1 | 7.80 |
| CHEMBL103442 | — | — | 1 | 7.64 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 7.60 |
| CHEMBL38851 | — | — | 1 | 7.33 |
| CHEMBL102459 | — | — | 1 | 7.21 |
| CHEMBL100805 | — | — | 1 | 7.16 |
| CHEMBL323148 | — | — | 1 | 7.15 |
| CHEMBL318795 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317508 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL75094 | PRINOMASTAT | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL317132 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL100584 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL323371 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL101121 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL103442 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL38851 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL102459 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL100805 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL323148 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL318795 | — | IC50 | = | 313.0 | nM | 6.50 |