Assay Detail
Binding
CHEMBL710132
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Inhibition of human matrix metalloprotease-3
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of phosphinamide-based hydroxamic acids as inhibitors of matrix metalloproteinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.03 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514138 | CGS-27023A | — | 1 | 7.77 |
| CHEMBL176602 | — | — | 1 | 7.61 |
| CHEMBL355752 | — | — | 1 | 7.17 |
| CHEMBL172857 | — | — | 1 | 6.16 |
| CHEMBL353479 | — | — | 1 | 6.16 |
| CHEMBL367420 | — | — | 1 | 5.98 |
| CHEMBL174037 | — | — | 1 | 5.80 |
| CHEMBL173208 | — | — | 1 | 5.76 |
| CHEMBL367675 | — | — | 1 | 5.59 |
| CHEMBL368946 | — | — | 1 | 5.04 |
| CHEMBL173207 | — | — | 1 | 4.99 |
| CHEMBL366759 | — | — | 1 | 4.31 |
| CHEMBL355754 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514138 | CGS-27023A | IC50 | = | 16.9 | nM | 7.77 |
| CHEMBL176602 | — | IC50 | = | 24.4 | nM | 7.61 |
| CHEMBL355752 | — | IC50 | = | 67.9 | nM | 7.17 |
| CHEMBL172857 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL353479 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL367420 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL174037 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL173208 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL367675 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL368946 | — | IC50 | = | 9170.0 | nM | 5.04 |
| CHEMBL173207 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL366759 | — | IC50 | = | 49300.0 | nM | 4.31 |
| CHEMBL355754 | — | IC50 | = | 130500.0 | nM | - |