Assay Detail
Functional
CHEMBL710149
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Cytotoxicity was evaluated against MCF7-R (mammary carcinoma 180-fold resistant to doxorubicin, expressing MDR phenotype) human breast cancer cell line
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7R |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of novel 3-trifluoromethyl taxoids
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.34 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29588 | — | — | 1 | 7.92 |
| CHEMBL263037 | — | — | 1 | 7.85 |
| CHEMBL282357 | — | — | 1 | 7.80 |
| CHEMBL431310 | — | — | 1 | 7.77 |
| CHEMBL283021 | — | — | 1 | 7.68 |
| CHEMBL287673 | — | — | 1 | 7.58 |
| CHEMBL413255 | — | — | 1 | 7.32 |
| CHEMBL286044 | — | — | 1 | 6.81 |
| CHEMBL283721 | — | — | 1 | 6.81 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 6.63 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29588 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL263037 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL282357 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL431310 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL283021 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL287673 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL413255 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL286044 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL283721 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 299.0 | nM | 6.52 |