Assay Detail
Functional
CHEMBL710185
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Cytotoxic effect on L1210 leukemia cells.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Solid phase organic synthesis of polyamine derivatives and initial biological evaluation of their antitumoral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.29 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423054 | — | — | 1 | 5.77 |
| CHEMBL422519 | — | — | 1 | 5.66 |
| CHEMBL158848 | — | — | 1 | 5.25 |
| CHEMBL156809 | — | — | 1 | 5.24 |
| CHEMBL345671 | — | — | 1 | 4.52 |
| CHEMBL440916 | — | — | 1 | - |
| CHEMBL156800 | — | — | 1 | - |
| CHEMBL156752 | — | — | 1 | - |
| CHEMBL346232 | — | — | 1 | - |
| CHEMBL156805 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423054 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL422519 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL158848 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL156809 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL345671 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL440916 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL156800 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL156752 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL346232 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL156805 | — | IC50 | > | 200000.0 | nM | - |