Assay Detail
Functional
CHEMBL710186
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Compound was tested for inhibitory concentration required to inhibit 50% of [14C]- putrescine uptake.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Solid phase organic synthesis of polyamine derivatives and initial biological evaluation of their antitumoral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.22 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423054 | — | — | 1 | 6.58 |
| CHEMBL422519 | — | — | 1 | 6.54 |
| CHEMBL156809 | — | — | 1 | 6.43 |
| CHEMBL23194 | SPERMINE | 0.5 | 1 | 6.41 |
| CHEMBL158848 | — | — | 1 | 6.41 |
| CHEMBL345671 | — | — | 1 | 6.34 |
| CHEMBL159020 | — | — | 1 | 4.84 |
| CHEMBL440916 | — | — | 1 | - |
| CHEMBL156800 | — | — | 1 | - |
| CHEMBL156752 | — | — | 1 | - |
| CHEMBL346232 | — | — | 1 | - |
| CHEMBL156805 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423054 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL422519 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL156809 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL23194 | SPERMINE | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL158848 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL345671 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL159020 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL440916 | — | IC50 | > | 170000.0 | nM | - |
| CHEMBL156800 | — | IC50 | > | 170000.0 | nM | - |
| CHEMBL156752 | — | IC50 | > | 170000.0 | nM | - |
| CHEMBL346232 | — | IC50 | > | 170000.0 | nM | - |
| CHEMBL156805 | — | IC50 | > | 170000.0 | nM | - |