Assay Detail
Functional
CHEMBL710187
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Concentration required to inhibit 50 percent growth of L1210 mouse leukemia cells
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.80 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104638 | — | — | 1 | 8.52 |
| CHEMBL70515 | — | — | 1 | 7.16 |
| CHEMBL434209 | — | — | 1 | 7.05 |
| CHEMBL40321 | — | — | 1 | 6.96 |
| CHEMBL323539 | — | — | 1 | 6.77 |
| CHEMBL104025 | — | — | 1 | 6.62 |
| CHEMBL44037 | — | — | 1 | 6.44 |
| CHEMBL322176 | — | — | 1 | 6.43 |
| CHEMBL104759 | — | — | 1 | 6.40 |
| CHEMBL103059 | — | — | 1 | 6.40 |
| CHEMBL103029 | — | — | 1 | 6.16 |
| CHEMBL319624 | — | — | 1 | 6.09 |
| CHEMBL104104 | — | — | 1 | 5.92 |
| CHEMBL102469 | — | — | 1 | 5.92 |
| CHEMBL104748 | — | — | 1 | 5.91 |
| CHEMBL105370 | — | — | 1 | 5.60 |
| CHEMBL105426 | — | — | 1 | 5.50 |
| CHEMBL389051 | — | — | 1 | 5.47 |
| CHEMBL321977 | — | — | 1 | 5.30 |
| CHEMBL105045 | — | — | 1 | 5.18 |
| CHEMBL321284 | — | — | 1 | 4.89 |
| CHEMBL105519 | — | — | 1 | 4.84 |
| CHEMBL104483 | — | — | 1 | 4.80 |
| CHEMBL104846 | — | — | 1 | 4.70 |
| CHEMBL102506 | — | — | 1 | 4.62 |
| CHEMBL274495 | — | — | 1 | 4.40 |
| CHEMBL102317 | — | — | 1 | 4.32 |
| CHEMBL317901 | — | — | 1 | 4.00 |
| CHEMBL105726 | — | — | 1 | - |
| CHEMBL420279 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104638 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL70515 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL434209 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL40321 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL323539 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL104025 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL44037 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL322176 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL104759 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL103059 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL103029 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL319624 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL104104 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL102469 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL104748 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL105370 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL105426 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL389051 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL321977 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL105045 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL321284 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL105519 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL104483 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL104846 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL102506 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL274495 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL102317 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL317901 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL105726 | — | IC50 | = | 125000.0 | nM | - |
| CHEMBL420279 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL105260 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL104694 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL319914 | — | IC50 | > | 100000.0 | nM | - |