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Assay Detail

CHEMBL710197

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth response in cultures of MCF-7 (human breast cancer cell line) cells
ChEMBL ↗
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Expert

Target

MCF7 (CHEMBL387) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Induction of the estrogen specific mitogenic response of MCF-7 cells by selected analogues of estradiol-17 beta: a 3D QSAR study.
Wiese TE, Polin LA, Palomino E, Brooks SC.
J Med Chem (1997) 40 : 3659 -3669
PubMed 9357533 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 42 9.20 10.91

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1627930 — — 1 10.91
CHEMBL123405 — — 1 10.90
CHEMBL1627568 — — 1 10.80
CHEMBL1627558 — — 1 10.79
CHEMBL1627936 — — 1 10.48
CHEMBL1627931 — — 1 10.44
CHEMBL193482 ESTRIOL 4.0 1 10.32
CHEMBL390714 — — 1 10.24
CHEMBL1405 ESTRONE 4.0 1 10.11
CHEMBL122509 — — 1 10.00
CHEMBL261406 — — 1 9.93
CHEMBL1627571 — — 1 9.90
CHEMBL1627570 — — 1 9.81
CHEMBL1627939 — — 1 9.76
CHEMBL1432305 — — 1 9.73
CHEMBL1627567 — — 1 9.62
CHEMBL194749 — — 1 9.50
CHEMBL1627566 — — 1 9.46
CHEMBL286452 ALFATRADIOL 2.0 1 9.42
CHEMBL1627946 — — 1 9.25
CHEMBL1627935 — — 1 9.05
CHEMBL123295 — — 1 8.85
CHEMBL1627933 — — 1 8.82
CHEMBL1627563 — — 1 8.80
CHEMBL1627569 — — 1 8.78
CHEMBL1628176 — — 1 8.77
CHEMBL1628180 — — 1 8.70
CHEMBL1627559 — — 1 8.67
CHEMBL316048 ANDROSTANEDIOL — 1 8.33
CHEMBL1627572 — — 1 8.32

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1627930 — EC50 = 0.0122 nM 10.91
CHEMBL123405 — EC50 = 0.0125 nM 10.90
CHEMBL1627568 — EC50 = 0.016 nM 10.80
CHEMBL1627558 — EC50 = 0.0163 nM 10.79
CHEMBL1627936 — EC50 = 0.033 nM 10.48
CHEMBL1627931 — EC50 = 0.0365 nM 10.44
CHEMBL193482 ESTRIOL EC50 = 0.0483 nM 10.32
CHEMBL390714 — EC50 = 0.0571 nM 10.24
CHEMBL1405 ESTRONE EC50 = 0.0772 nM 10.11
CHEMBL122509 — EC50 = 0.099 nM 10.00
CHEMBL261406 — EC50 = 0.118 nM 9.93
CHEMBL1627571 — EC50 = 0.127 nM 9.90
CHEMBL1627570 — EC50 = 0.153 nM 9.81
CHEMBL1627939 — EC50 = 0.174 nM 9.76
CHEMBL1432305 — EC50 = 0.186 nM 9.73
CHEMBL1627567 — EC50 = 0.237 nM 9.62
CHEMBL194749 — EC50 = 0.316 nM 9.50
CHEMBL1627566 — EC50 = 0.346 nM 9.46
CHEMBL286452 ALFATRADIOL EC50 = 0.382 nM 9.42
CHEMBL1627946 — EC50 = 0.558 nM 9.25
CHEMBL1627935 — EC50 = 0.9 nM 9.05
CHEMBL123295 — EC50 = 1.41 nM 8.85
CHEMBL1627933 — EC50 = 1.5 nM 8.82
CHEMBL1627563 — EC50 = 1.59 nM 8.80
CHEMBL1627569 — EC50 = 1.67 nM 8.78
CHEMBL1628176 — EC50 = 1.7 nM 8.77
CHEMBL1628180 — EC50 = 2.0 nM 8.70
CHEMBL1627559 — EC50 = 2.16 nM 8.67
CHEMBL316048 ANDROSTANEDIOL EC50 = 4.66 nM 8.33
CHEMBL1627572 — EC50 = 4.76 nM 8.32
CHEMBL1628041 — EC50 = 8.97 nM 8.05
CHEMBL1627927 — EC50 = 28.4 nM 7.55
CHEMBL1627562 — EC50 = 29.3 nM 7.53
CHEMBL1627573 — EC50 = 33.5 nM 7.47
CHEMBL1627565 — EC50 = 34.2 nM 7.47
CHEMBL1628162 — EC50 = 60.4 nM 7.22
CHEMBL1627934 — EC50 = 201.0 nM 6.70
CHEMBL135 ESTRADIOL EC50 = 0.00152 nM -
CHEMBL389704 — EC50 = 0.00338 nM -
CHEMBL335062 ANDROSTANDIOL EC50 > 10000.0 nM -
CHEMBL330851 — EC50 = 0.00419 nM -
CHEMBL121458 — EC50 = 0.00154 nM -