Assay Detail
Functional
CHEMBL710203
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Compound was tested for its toxicity against human breast cancer cells(MCF-7)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Epidoxoform: a hydrolytically more stable anthracycline-formaldehyde conjugate toxic to resistant tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.41 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406294 | DOXOFORM | — | 1 | 8.70 |
| CHEMBL429955 | DAUNOFORM | — | 1 | 8.10 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 7.22 |
| CHEMBL611158 | EPIDOXOFORM | — | 1 | 7.19 |
| CHEMBL417 | EPIRUBICIN | 4.0 | 1 | 6.70 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406294 | DOXOFORM | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL429955 | DAUNOFORM | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL611158 | EPIDOXOFORM | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL417 | EPIRUBICIN | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 300.0 | nM | 6.52 |