Assay Detail
Functional
CHEMBL710206
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Concentration required to inhibit growth of human tumor MCF-7 (breast) cell line.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 9.41 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421653 | — | — | 1 | 10.05 |
| CHEMBL339370 | — | — | 1 | 9.89 |
| CHEMBL340250 | — | — | 1 | 9.85 |
| CHEMBL126678 | — | — | 1 | 9.74 |
| CHEMBL419594 | — | — | 1 | 9.70 |
| CHEMBL126916 | — | — | 1 | 9.70 |
| CHEMBL340628 | — | — | 1 | 9.59 |
| CHEMBL339521 | — | — | 1 | 9.55 |
| CHEMBL339518 | — | — | 1 | 9.51 |
| CHEMBL338139 | — | — | 1 | 9.48 |
| CHEMBL338256 | — | — | 1 | 9.48 |
| CHEMBL420349 | — | — | 1 | 9.46 |
| CHEMBL340719 | — | — | 1 | 9.44 |
| CHEMBL340127 | — | — | 1 | 9.44 |
| CHEMBL338714 | — | — | 1 | 9.43 |
| CHEMBL339283 | — | — | 1 | 9.40 |
| CHEMBL125399 | — | — | 1 | 9.40 |
| CHEMBL340030 | — | — | 1 | 9.40 |
| CHEMBL129126 | — | — | 1 | 9.40 |
| CHEMBL341465 | — | — | 1 | 9.36 |
| CHEMBL339519 | — | — | 1 | 9.34 |
| CHEMBL435607 | — | — | 1 | 9.34 |
| CHEMBL340031 | — | — | 1 | 9.30 |
| CHEMBL127450 | — | — | 1 | 9.29 |
| CHEMBL339531 | — | — | 1 | 9.26 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.00 |
| CHEMBL419616 | — | — | 1 | 8.80 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.77 |
| CHEMBL126932 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421653 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL339370 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL340250 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL126678 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL419594 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL126916 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL340628 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL339521 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL339518 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL338139 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL338256 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL420349 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL340719 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL340127 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL338714 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL339283 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL125399 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL340030 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL129126 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL341465 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL339519 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL435607 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL340031 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL127450 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL339531 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL419616 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL126932 | — | IC50 | = | 4.0 | nM | 8.40 |