Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL710207

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration which produces 50% inhibition of growth of human breast tumor MCF-7 cell line
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Intermediate

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Combretoxazolones: synthesis, cytotoxicity and antitumor activity.
Nam NH, Kim Y, You YJ, Hong DH, Kim HM, Ahn BZ.
Bioorg Med Chem Lett (2001) 11 : 3073 -3076
PubMed 11714613 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 8.06 8.74

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL106389 1 8.74
CHEMBL67 COMBRETASTATIN A4 -1.0 1 8.57
CHEMBL101859 1 8.54
CHEMBL450580 1 8.43
CHEMBL321541 1 8.31
CHEMBL432002 1 8.24
CHEMBL323781 1 7.98
CHEMBL104148 1 7.78
CHEMBL317190 1 7.55
CHEMBL107801 1 7.40
CHEMBL321299 1 7.11

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL106389 IC50 = 1.8 nM 8.74
CHEMBL67 COMBRETASTATIN A4 IC50 = 2.7 nM 8.57
CHEMBL101859 IC50 = 2.9 nM 8.54
CHEMBL450580 IC50 = 3.7 nM 8.43
CHEMBL321541 IC50 = 4.9 nM 8.31
CHEMBL432002 IC50 = 5.7 nM 8.24
CHEMBL323781 IC50 = 10.5 nM 7.98
CHEMBL104148 IC50 = 16.7 nM 7.78
CHEMBL317190 IC50 = 28.4 nM 7.55
CHEMBL107801 IC50 = 39.7 nM 7.40
CHEMBL321299 IC50 = 78.5 nM 7.11