Assay Detail
Functional
CHEMBL710208
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Inhibition of 17-beta-estradiol (10e-11 M) mediated MCF-7 cell proliferation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF-7 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of trans-2,3-dihydroraloxifene.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.77 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL537254 | — | — | 1 | 10.30 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 9.47 |
| CHEMBL14955 | DIHYDRORALOXIFENE | — | 1 | 9.28 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL537254 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL14955 | DIHYDRORALOXIFENE | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 904.0 | nM | 6.04 |